Note: this is a wiki article
Working:
1Password 7.3.0
4D 17.2 Hot Fix 1
Ableton Live 10 Lite
Adapter
AdGuard for Safari (2.0.4.552)
AdGuard for Mac
Adobe After Effects CC 2019 (16.1.1)
Adobe Audition
Adobe Illustrator 2019
Adobe Lightroom Classic CC 2019 (8.2 & 8.3)
Adobe Photoshop 2019
Adobe Premiere Pro CC 2019 (13.1)
Affinity Designer (1.6.11 & 1.7.0)
Affinity Photo (1.6.11 & 1.7.0)
Affinity Publisher (1.7.1)
Airmail 3
Alfred
Anki 2.1.13
Arq
Audio Hijack (gives warning OS is unsupported but allows bypass however audio capture broken)
Aurora HDR 2019
Autodesk Eagle 9
Banktivity 7 (7.3.1, earlier versions crash from beta 6 onwards)
Bartender
BBEdit
BetterTouch Tool 3.080
BiglyBT
Calibre
Cardhop
Chrome
Cisco AnyConnect
Citrix Receiver for Mac (Beta) 19.09.013
CleanMyMac X Version 4.4.2
CoconutBattery
Copied
Custom Menu
Cyberduck
Daisy Disk 4.7.2
DaVinci Resolve 16 (Beta)
Deliveries
Default Folder X (beta version: 5.4b2 (1633), current released version doesn't work)
Dictionaries
Discord
Display Menu 2.2.3
DJay Pro 2
Dropbox
Dropzone 3
EtreCheck Pro
Evernote
Dymo Labler
Drobo Dashboard 3.4.2
Enpass
ETC Nomad (2.9 Open Beta works - 64-bit update) - aka. ETC EOS Family Consoles
Farrago (gives warning that OS is unsupported but allows bypass)
Feedly
Final Cut Pro X (10.4.6) - Fixed in Developer Beta 2
Firefox
Fission (gives warning that OS is unsupported but allows bypass)
FL Studio
Fluid
Forecast Bar
ForkLift
GIMP 2.10
Google Drive File Stream
Google Earth Pro 7.3.2.5776
Handbrake
HazeOver
HyperDock
iBackup - Password Manager - needs java 6
iFlicks 2
iFlicks 3
IINA 1.0.4
iStats Menus (light/dark mode switching appears to be reversed)
ItsyCal
JetBrains DataGrip
Jump Remote Desktop
Jumpshare
LaunchControl
LaunchPad Manager 1.0.9
Little Snitch (firewall client) (Version 4.4 nightly 5403)
Logic Pro X (since b6)
Logitech Options 7.12.82
Luminar 3
Keka File Archiver
Kindle
Macs Fan Control 1.4.12
Magnet
MakeMKV
MalwareBytes
MAMP PRO (just very slow)
Maplesoft Maple 2019.1
Marta 0.7
Maschine 2
Microsoft InTune Company Portal 1.14
Microsoft Remote Desktop (v10.2.x)
Microsoft Teams
Mousecape
MS Edge Dev Insider Preview
MS Excel
MS Outlook
MS Powerpoint
MS Skype for Business (v16.23.64 & v16.27.26 crash when connecting to meeting) (v16.27.37 crashes every time someone starts screen sharing)
MS Word
MultiMC
MuseScore 3
myTuner Radio 2.1
Native Access (and all tested NI plugins/apps)
NordVPN
Notability
Note2 Txt
OmniFocus Pro 3.3.2
OmniGraffle Pro 7.10.2
OmniPlan Pro 3.12.13
OneDrive - fixed as of Insider Build 19.086.0502.0007
OneNote
OpenEmu 2.0.9.1
Opera
Paperless (3.0.5)
Papers 3.4.2
Parallels Desktop -USB Support issue resolved after DP2 update
Path Finder 8.6
PCS60 (SpliceCom phone software) 4.0.103
Permute 3
PhotoLemur 3
Piezo (gives warning that OS is unsupported but allows bypass)
Pixelmator (locks up at launch)
Pixelmator Pro
PopcornTime
Private Internet Access v1.2.1
PureVPN
Quickbooks
RoyalTSX 4.1.1
Screens VNC 4
Scrivener - issue on displaying binder contents seems to be fixed.
SecuritySpy 5.01
Shazam
Sip
Sketch
Skitch
Slack
SlimBatteryMonitor
Sonicwall Mobile Connect
Soundsource 4.1.4
Spark
Speedtest
Splice
Starry Night Pro Plus 7.6.5
Steam (download it again from steam website to get the 64bit version)
Subler
TacticalSailing (Manual installation of Java 1.6 required)
Telegram
TextExpander (light/dark mode switching appears to be reversed)
The Unarchiver
Things
TorGuard
TotalFinder
Transmission (crashes a lot though!)
Trello
Twitch
Tweetbot
Ulysses. First launch took forever.
Uplet
Virtual Office (8x8 desktop softphone) - version 6.1.2
Viscosity
Visual Paradigm 15.2
VLC 3.0.6
VMWare Fusion (11) and much better with version 11.5
VMWare Fusion Pro (11.1.0)
VNC Viewer
WhatsApp
WiFi Explorer
World of Warcraft/Battle for Azeroth
XMind Zen 9.1.3
XtraFinder 1.5.1
Zoc Terminal 7.23.6
Zoom Cloud meetings - with latest update Zoom is working
Zwift
Not Working:
4D all versions less than 17.2.238521
Adobe Acrobat Pro DC (Installation fails - Confirmed by Adobe Technical Support)
Adobe Photoshop CC 14 - Opens, then almost immediately closes
AirBuddy - causes kernel panics
Agile Commander 1.2.2
Aperture - time to say goodbye
Backblaze
BlueStacks - Opens, on loading bar, it asks permission for something and will not progress further.
Box Drive 2.6.186 -> nor working (reports that the version of the OS is not supported and quits)
CHM View
Citrix Workspace - invalid certificate issue with the native Apple app. Workaround is to use the Google Chrome store version
Compressor 4.4.4 - Produces several intermediate files but not the actual output file
CrossOver 18.5.0
Disk Inventory X 1.2 (compatible beta is being worked on)
DiskWarrior 5.2
Drobo Dashboard 3.4.2
Easy Find - crashes after starting to run
EasyRes - crashes on startup
ETC Nomad (2.8 won't start as still 32-bit) - aka. ETC EOS Family Consoles
Exactscan Pro (crashes on start)
ExpanDrive (crashes on start)
ExpressVPN - Says can't detect connection
Fantastical (crashes repeatedly in dev beta 5)
Final Cut Pro 10.3.4
Galaxy Watch Designer
GoToMeeting - check support page for system checker
Goodtask
GPGMail
LiteIcon 3.9.0
IK Multimedia Custom Shop & Authorization Manager (32b apps).
Letter Opener
LogMeIn Control Panel version 4.1.10331
LogMeIn Rescue
Loopback
MailSuite (SmallCubed Software)
Max
mTorrent
MyHarmony - Logitech just announced beta of 64-bit version but will *never* support hub-based remotes: https://support.logi.com/hc/en-us/community/posts/360034696754
OBS
OverDrive
PackageMaker
Path Finder 8.5.1 - crashes/freezes main browser window, PF desktop still works.
Path Finder 8.6 does work.
Picassa
Plantronics Hub 3.13.1 - headset (Savi W740-M) disconnects when muting or unmuting while on a
RadioSHARK
Raptors Call of the Shadows (needs to be updated to 32-bit)
Radium 3.1.3
Rosetta Stone 5.0.37 (32-bit)
Samsung Smart Switch
SNS globalSAN iSCSI Initiator (still 32 bit, unfortunately)
Skype for Business call, my AirPods work with SFB just fine, so this appears to be a Plantronics issue; also crashes when exiting the program
Safari Technology Preview v12.2 (Update now available from STP website for Catalina)
Scansnap Manager for Evernote (32-bit won't run)
SoundSource 4 Download version 4.1.4
SwitchResX - Beta for Catalina available on author's website
Thunderbird - Had been fine during early Betas but after DB5 crashes on startup.
Text Wrangler
The Sims 4
ThemeEngine (For theming macOS) (Crashes on opening a .car file)
Transmission (crashes when completing a download)
Two Point Hospital
Virtualbox 6.0.8. VM runs until you switch to a different app.
uBar (uBar dock disappears)
Utorrent (still 32-bit)
Winclone 7.3.4
WINE (no longer supported by macOS Catalina )
Xtra Finder 1.5.0 (upgrade to 1.5.1)
Partially working:
Sears subtitle editor - Doesn't run from icon, but works if you dig into the bundle and open the .jar directly
Karabiner Elements - requires workarounds